Original Article Tumor Volume and Uterine Body Invasion Assessed by MRI for Prediction of Outcome in Cervical Carcinoma Treated

Objective: The aim of this study was to evaluate the prognostic significance of primary tumor volume and uterine body invasion assessed by pre-treatment MRI for uterine cervical cancer patient treated with concurrent chemotherapy and radiotherapy. Methods: A retrospective analysis of 106 patients with IB–IIIB cervical carcinoma was per-formed. Potential prognostic factors were stage, clinical tumor diameter, histology, age, pelvic lymph node, vaginal extension, parametrial invasion, tumor volume and uterine body invasion status. Multivariate analyses were performed to identify the prognostic factor for overall survi-val (OS) and disease-free survival (DFS). Results: The 5-year OS, DFS rate were 59.7 and 56.6%. Using multivariate analyses, a large tumor volume (30 ml; P 0.012) and uterine body invasion (P 0.020) and positive pelvic lymph node (LN) enlargement (P 0.040) showed a significantly unfavorable influence on OS. Using these three factors, patients were divided into four subgroups: the OS rates of patients with risk 0 (volume,30 ml, no uterine body invasion, and negative LN), risk 1 (one of these three factors), risk 2 (two of these three factors) and risk 3 (volume 30 ml, uterine body invasion, and positive LN) were 96.3, 77.5, 53.0 and 14.8%, respectively (P, 0.0001)