Crystal Structures of Vascular Endothelial Growth Factor in Complex with Fab Fragments

Vascular endothelial growth factor (VEGF) is a cell-selective mitogen for vascular endothelial cells [1]. As a potent angiogenic factor it is required for the development of the vascular system and has been implicated in pathological processes such as tumor growth, metastasis, diabetic retinopathy and rheumatoid arthritis [2]. Neutralizing antibodies against VEGF are capable of suppressin