Tumor rejection by disturbing tumor stroma cell interactions

The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10. Be-ginning 6 h after Cy-treatment T cells in the tumor were inactivated and TIMs switched to in-terferon (IFN)