Topics
T-lymphocytesAnatomical structure
HLA-A3Species
HLABiomolecule
major histocompatibility complex (MHC)Biomolecule
MALDI TOFElection
antigenChemical compound
MALDIElection
Identification of major histocompatibility complex (MHC)-associated peptides recognized by T-lymphocytes is a crucial prerequisite for the detection and manipulation of specific immune responses in cancer, viral infections, and autoimmune diseases. Unfortunately immunogenic pep-tides are less abundant species present in highly complex mixtures of MHC-extracted material. Most peptide iden-tification strategies use microcapillary LC coupled to nano-ESI MS/MS in a challenging on-line approach. Alter-natively MALDI PSD analysis has been applied for this purpose. We report here on the first off-line combination of nanoscale (nano) LC and MALDI TOF/TOF MS/MS for the identification of naturally processed MHC peptide li-gands. These peptides were a...
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides pres...
<div><p>Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II pepti...
Major histocompatibility complex class I (MHC I) plays a crucial role in the development of adaptive...
Identification of major histocompatibility complex (MHC)-associated peptides recognized by T-lymphoc...
Peptide antigens bound to molecules encoded by the major histocompatibility complex (MHC) and presen...
Major histocompatibility complexes (MHC) play a critical role in immunity by presenting peptides on ...
Neoantigen-based therapeutic vaccines have a high potential impact on tumor eradication and patient ...
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of m...
Mass spectrometry-based immunopeptidomics enables the comprehensive identification of major histocom...
The use of microdialysis sampling and flow immunochemical detection as well as MALDI-TOF MS for pept...
Personalized multipeptide vaccines are currently being discussed intensively for tumor immunotherapy...
MHC class I (MHC-I)-bound ligands play a pivotal role in CD8 T cell immunity and are hence of major ...
Major histocompatibility complex class II (MHC II) molecules are expressed on the surface of antigen...
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules aft...
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides pres...
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides pres...
<div><p>Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II pepti...
Major histocompatibility complex class I (MHC I) plays a crucial role in the development of adaptive...
Identification of major histocompatibility complex (MHC)-associated peptides recognized by T-lymphoc...
Peptide antigens bound to molecules encoded by the major histocompatibility complex (MHC) and presen...
Major histocompatibility complexes (MHC) play a critical role in immunity by presenting peptides on ...
Neoantigen-based therapeutic vaccines have a high potential impact on tumor eradication and patient ...
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of m...
Mass spectrometry-based immunopeptidomics enables the comprehensive identification of major histocom...
The use of microdialysis sampling and flow immunochemical detection as well as MALDI-TOF MS for pept...
Personalized multipeptide vaccines are currently being discussed intensively for tumor immunotherapy...
MHC class I (MHC-I)-bound ligands play a pivotal role in CD8 T cell immunity and are hence of major ...
Major histocompatibility complex class II (MHC II) molecules are expressed on the surface of antigen...
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules aft...
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides pres...
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides pres...
<div><p>Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II pepti...
Major histocompatibility complex class I (MHC I) plays a crucial role in the development of adaptive...
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