10.1177/1534735405285882MossAntioxidants With Chemotherapy and Radiotherapy Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants?

lished a warning by Gabriella D’Andrea, MD, against the con-current use of antioxidants with radiotherapy and chemotherapy. However, several deficiencies of the CA arti-cle soon became apparent, not least the selective omission of prominent studies that contradicted the author’s conclusions. While acknowledging that only large-scale, randomized trials couldprovide a valid basis for therapeutic recommendations, the author sometimes reliedon laboratory rather than clinical data to support her claim that harm resulted from the concur-rent use of antioxidants and chemotherapy. She also some-times extrapolated from chemoprevention studies rather than those on the concurrent use of antioxidants per se. The article overstated the degree to which the laboratory data di-verged in regard to the safety and efficacy of antioxidant ther-apy: in fact, the preponderance of data suggests a synergisti