Guidelines for the treatment of persons with influenza virus infection were prepared by an Expert Panel of the Infectious Diseases Society of America. The evidence-based guidelines encompass diagnostic issues, treat-ment and chemoprophylaxis with antiviral medications, and issues related to institutional outbreak manage-ment for seasonal (interpandemic) influenza. They are intended for use by physicians in all medical specialties with direct patient care, because influenza virus infection is common in communities during influenza season and may be encountered by practitioners caring for a wide variety of patients. EXECUTIVE SUMMARY Background Influenza virus infection causes significant morbidity and mortality in the United States each year...