Solubility Enhancement of Curcumin from Turmeric Oleoresin by Solid Dispersion Technique

Abstract: The experiment was conducted to improve recovery and solubility of curcumin from Turmeric oleoresin (TO) by carrier (Polyethylene glycol 400, PEG 400) and adsorbent (Megnesium oxide, MgO) using the solid dispersion (SD) technique. The TO was mixed at the same ratio with carrier (1:1, w/w) and MgO was applied at a ratio of 0, 1, 2, 3 and 4 respectively. Mixed samples were determined for recovery solubility of curcumin quantity using the HPLC. The results showed that difference level of adsorbent had no effect on curcumin quantity. The ratio of 1:1:3 (TO: PEG 400: MgO) showed the highest recovery rate (81.47%). This ratio also showed higher solubility in water, while the ratio of 1:1:4 showed higher solubility in the 0.1 N hydrochloric acid solution (0.1 N HCl). It can be conducted that TO can be used as the source of curcumin in animal diet by mixed with carrier and adsorbent. The ratio of TO: carrier: adsorbent at 1:1:3 produced the highest recovery and solubility in water and in 0.1 N HCl