Clinical Genome Informatics (CGI) and its Social Informational Infrastructure

CGI is an essential informatics to support genomic medicine that is a medicine based on genome information. We believe that CGI domain must be a key technological field to establish the gene based medicine or pharmacogenomics. We analyzed the requirements to the social informational infrastructure in CGI domain and have developed the required technologies. In concrete terms, the coupling technology of the electronic health record (EHR) and the database is a technological basis. The public key infrastructure (PKI) is also important to secure the genome information that is ultimate personal information. Sharing tracks with the translational research informatics (TRI) is also required to make CGI practical and public. The CGI is inevitable and essential to establish the genomic medicine that is one of the goals of the post genomic researches. This paper reviews the definition, its requirements, its technological background, and the perspectives of CGI, and then discusses about the social informational infrastructure that is demanded in CGI domain. Key words