Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell 2003;12:889–901

Recruitment of Existing mRNAs to Polysomes tion pathways are significantly elevated relative to both normal brain and lower grade gliomas. For instance, the activity of Ras is elevated in all GBMs tested (Guha et al., 1997) and Akt activity is also elevated in a majority of these tumors (Holland et al., 2000). Animal modelin