Differences in perspectives about regulatory structures are also related to differences in concept and representation of dynamical processes. Describing individual gene effects begins with identifying individual genes, mechanisms of gene interactions, and pathways of gene products. Describing attractors involves characterizing the convergence of transcriptome wide cell states where majorities of genes determine behavior rather than any one. The difference between low dimensional (few variable) and high dimensional (many variable) collective dynamics is central. Characterizing cellular regulatory networks more generally as distributed control systems where individual genes can exert strong influence requires bridging these two views. We desc...
Cells adapt to changes in environmental conditions through the concerted action of signalling, gene ...
International audienceThe evolution of gene expression is constrained by the topology of gene regula...
Contains fulltext : 69195.pdf (publisher's version ) (Open Access)To what extent c...
Living cells can maintain their internal states, react to changing environments, grow, differentiate...
University of Minnesota Ph.D. dissertation. June 2013. Major:Chemical Engineering. Advisors: Yiannis...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2004.Includes bibliographi...
The proteins associated with gene regulation are often shared between multiple pathways simultaneous...
In any given cell, thousands of genes are expressed and work in concert to ensure the cell\u27s func...
This thesis presents the results of mathematical modeling of both individual genes and small network...
Life as we know it is based on cells that use proteins and RNA to carry out metabolism, self-replica...
Department of Biological SciencesUnderstanding regulatory networks and gene regulation, in particula...
Grouping genes by similarity of expression across multiple cellular conditions enables the identific...
AbstractRevealing the control mechanisms responsible for the cell’s surprisingly well-organized func...
Living cells are the product of gene expression programs involving regulated transcription of thousa...
Recently, major progress has been made to develop computational models to predict and explain the me...
Cells adapt to changes in environmental conditions through the concerted action of signalling, gene ...
International audienceThe evolution of gene expression is constrained by the topology of gene regula...
Contains fulltext : 69195.pdf (publisher's version ) (Open Access)To what extent c...
Living cells can maintain their internal states, react to changing environments, grow, differentiate...
University of Minnesota Ph.D. dissertation. June 2013. Major:Chemical Engineering. Advisors: Yiannis...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2004.Includes bibliographi...
The proteins associated with gene regulation are often shared between multiple pathways simultaneous...
In any given cell, thousands of genes are expressed and work in concert to ensure the cell\u27s func...
This thesis presents the results of mathematical modeling of both individual genes and small network...
Life as we know it is based on cells that use proteins and RNA to carry out metabolism, self-replica...
Department of Biological SciencesUnderstanding regulatory networks and gene regulation, in particula...
Grouping genes by similarity of expression across multiple cellular conditions enables the identific...
AbstractRevealing the control mechanisms responsible for the cell’s surprisingly well-organized func...
Living cells are the product of gene expression programs involving regulated transcription of thousa...
Recently, major progress has been made to develop computational models to predict and explain the me...
Cells adapt to changes in environmental conditions through the concerted action of signalling, gene ...
International audienceThe evolution of gene expression is constrained by the topology of gene regula...
Contains fulltext : 69195.pdf (publisher's version ) (Open Access)To what extent c...