Licensed Under Creative Commons Attribution CC BY Cytotoxic and Antiproliferative Activity of Indian Medicinal Plants in Cancer Cells

Abstract: In the present study, six Indian medicinal plants (Pavoniaodorata, Gardenia latifolia, Canthiumdicoccum, Limoniamonophylla, Brideliaroxburghiana and Wrightiatinctoria) are mainly focused for cytotoxicity and anti-proliferating property.Crude methanol extract is obtained for each plant extract using a soxhlet apparatus. 10 mg/ml of extracts of each plant are tested for MTT assay using Calu-6, Colo-205 and HL-60 cells. Based upon the result MTT assay PavoniaodorataandWrightiatinctoria were selected for wound healing assay and cell cycle analysis using Calu-6 cells. Inwound healing assay the migration effect is determined. In case of cell cycle analysis, percentage is determined for the plant- Pavoniaodorata and Wrightiatinctoria. Pavoniaodorata and Wrightiatinctoria showed cytotoxicity and anti-proliferating property for the cancer cell mainly in Calu-6 cells.Hence Pavoniaodorata and Wrightiatinctoria were selected for further assay on the extracts pharmacokinetics and toxicology study should be carried out to support this in vitro assay before in vivo or clinical test is being carried out