Effect of zinc supplementation between 1 and 6 mo of life on growth and morbidity of Bangladeshi infants in urban slums1–3

Background: Evidence for an effect of zinc supplementation on growth and morbidity in very young infants in developing coun-tries is scarce and inconsistent. Objective: We assessed the effect of zinc supplementation on growth and morbidity in poor Bangladeshi infants aged 4–24 wk. Design: Infants from Dhaka slums were enrolled at 4 wk of age and randomly assigned to receive 5 mg elemental Zn/d (n = 152) or placebo (n = 149) until 24 wk of age. They were followed weekly for information on compliance and morbidity; anthropo-metric measurements were performed monthly. Serum zinc was assessed at baseline and at 24 wk of age. Results: At 24 wk of age, serum zinc concentrations were higher in the zinc than in the placebo group (13.3 ± 3.8 and 10.7 ± 2.9 mol/ L, respectively; P < 0.001). Significantly greater weight gains were observed in the zinc than in the placebo group for 43 infants who were zinc deficient (< 9.18 mol/L) at baseline (3.15 ± 0.77 and 2.66 ± 0.80 kg, respectively; P < 0.04). In the other infants, no significant differences were observed in mean weight and length gains during the study period. Zinc-deficient infants showed a reduced risk of incidence of acute lower respiratory infection after zinc supplementation (relative risk: 0.30; 95 % CI: 0.10, 0.92); among the non-zinc-deficient infants there were no significant dif-ferences between treatment groups. Conclusions: Zinc-deficient Bangladeshi infants showed improvements in growth rate and a reduced incidence of acute lower respiratory infection after zinc supplementation. In infants with serum zinc concentrations> 9.18 mol/L, supplementation improved only biochemical zinc status. Am J Clin Nut