From the Servicio de Hemoterapia-Hemostasia,

Granulocyte colony-stimulating factor increases expression of adhesion receptors on endothelial cells through activation of p38 MAPK Granulocyte colony-stimulating factor(G-CSF) is the major growth factorresponsible for regulating granu-lopoiesis and promoting the survival, prolif-eration, functional activation, and matura-tion of cells of the neutrophil lineage.1 G-CSF also promotes mobilization of CD34+ hematopoietic progenitor cells to circulating blood. Recombinant G-CSF is widely used to induce mobilization of blood precursors in different clinical settings such as chemo-therapy-induced myelosuppression and peri-pheral blood stem cell collection for autol-ogous and allogeneic bone marrow trans