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ta an re h a occurring disease. Recently it has been shown that supplementation of vitamins E and C and in cats with chronic renal failure, consistent reduced in lymphocyte subsets of patients with correlated with a poor survival in AIDS patients (Herzenberg et al 1997). Glutathione homeostasis enzymes including superoxide dismutase (SOD). developed. The gliadin serves to protect the SOD from degradation, allows for delayed re-Journal of Feline Medicine and Surgery (2008) 10, 423e430 doi:10.1016/j.jfms.2008.01.008HIV. In vitro studies show that decreasing intra-with a reduction in free radical-induced damage to DNA (Yu and Paetau-Robinson 2006). Oxidative stress plays a significant role in the pathogenesis and progression of human immu-nodeficiency virus (HIV) infection. Reduced glu-tathione (GSH), the predominant endogenous antioxidant in mammalian cells, is significantly SOD enzyme catalyzes the metabolism of the superoxide anion to hydrogen peroxide, and eventually, through a reaction catalyzed by the catalase enzyme, water. Oral supplementation of SOD would be susceptible to gastric degrada-tion. A proprietary plant-derived SOD, com-plexed to the protein gliadin, has beenb-carotene decreased serum levels of 8-OHdG relies on the activity of a number of antioxidantDate accepted: 17 January 2008 D espite the signific stress in felines, the ports documenting t dant supplementation in ccellular GSH concentratio