Evaluation of Induced Variance of Physical Parameters on the Calibrated USP Dissolution Apparatus 1 and 2

The dissolution test consists of two parts;the prepa-ration of the sample which is performed with the dissolution apparatus,and the analytical finish which is typically performed with HPLC or UV spectropho-tometry. Modern dissolution apparatus provide an environment for sample preparation whereby samples removed at various times are analyzed to illustrate the rate at which the active pharmaceutical ingredient typically releases from solid oral dosage forms. Dissolution apparatus are manufactured to precisely control physical parameters,test conditions and alignment to ensure that the release of drug from a dosage form will be determined consistently from one location to another.While the dissolution test is subject to variability resulting from many source