Special Issue Article Hyaluronan Regulates Ceruloplasmin Production By Gliomas and Their

ferroxidase associated with normal astrocytes) can also be secreted by glioma cells, where its function is unknown. Ceruloplasmin is not only present in glioma cells and in human glioma specimens but also is enriched in highly malignant glioma stem-like cells. Hyaluronan is a large extracellular glycosaminoglycan that enhances malignant glioma behaviors by interacting with CD44 receptors and by downstream activation of signaling proteins and trans-porters associated with malignancy. We examined the relationship between hyaluronan and ceruloplasmin expression in glioma stem-like cells. Antagonism of hyaluronan interactions with short-fragment hyaluronan oligomers decreased ceruloplasmin expression in parental and stem-like glioma cells in vivo and in cell culture, implying thathyaluronan regulatesceruloplasminexpression. Further gain and loss-of-function studies are needed to fully define the relationship between hyaluronan and ceruloplas-min, and ceruloplasmin’s effect on malignant behaviors