recombination through synapsis and cleavage of a 12/23 pair of V(D)J recombination signal sequences (RSS). RAG-RSS complex assembly and activity in vitro is promoted by high mobility group proteins of the "HMG-box" family, exemplified by HMGB1. How HMGB1 stimulates the DNA binding and cleavage activity of the RAG complex remains unclear. HMGB1 contains two homologous HMG-box DNA binding domains, termed A and B, linked by a stretch of basic residues to a highly acidic C-terminal tail. To identify determinants of HMGB1 required for stimulation of RAG-mediated RSS binding and cleavage, we prepared an extensive panel of mutant HMGB
Eukaryotes regulate gene expression and other nuclear processes through the posttransla-tional modif...
Repair of DNA breaks by single-strand annealing (SSA) is a major mechanism for the main-tenance of g...
D ow nloaded from 2 Active equi-paritioning of the F plasmid is achieved by its sopABC gene. SopA bi...
During V(D)J recombination, recombination activating gene (RAG)1 and RAG2 bind and cleave recombinat...
V(D)J recombination generates a diverse repertoire of antigen receptors by somatically recombining ...
Ed forms of truncated RAG1 (384–1040) and RAG2 (1–387) (cMR1 and cMR2, respectively) were coexpresse...
Ed forms of truncated RAG1 (384–1040) and RAG2 (1–387) (cMR1 and cMR2, respectively) were coexpresse...
The Recombination Activating Genes, RAG1 and RAG2, are essential for V(D)J recombination and adaptiv...
HMGB1 protein and linker histone H1 have overlapping binding sites in the nucleosome. HMGB1 has been...
Initiation of V(D)J recombination involves the synapsis and cleavage of a 12/23 pair of recombinatio...
ow nloaded from Transcription drives supercoiling which forms and stabilizes ssDNA secondary structu...
The recombination activating gene (RAG) is a lymphoid-specific endonuclease involved in the V(D)J re...
Piwi-interacting piRNAs are a major and essential class of small RNAs in the animal germ cells with ...
Abstract: The MobM relaxase (494 amino acids) encoded by the promiscuous streptococcal plasmid pMV15...
High mobility group box (HMGB) proteins are non-histone architectural proteins that bind to and bend...
Eukaryotes regulate gene expression and other nuclear processes through the posttransla-tional modif...
Repair of DNA breaks by single-strand annealing (SSA) is a major mechanism for the main-tenance of g...
D ow nloaded from 2 Active equi-paritioning of the F plasmid is achieved by its sopABC gene. SopA bi...
During V(D)J recombination, recombination activating gene (RAG)1 and RAG2 bind and cleave recombinat...
V(D)J recombination generates a diverse repertoire of antigen receptors by somatically recombining ...
Ed forms of truncated RAG1 (384–1040) and RAG2 (1–387) (cMR1 and cMR2, respectively) were coexpresse...
Ed forms of truncated RAG1 (384–1040) and RAG2 (1–387) (cMR1 and cMR2, respectively) were coexpresse...
The Recombination Activating Genes, RAG1 and RAG2, are essential for V(D)J recombination and adaptiv...
HMGB1 protein and linker histone H1 have overlapping binding sites in the nucleosome. HMGB1 has been...
Initiation of V(D)J recombination involves the synapsis and cleavage of a 12/23 pair of recombinatio...
ow nloaded from Transcription drives supercoiling which forms and stabilizes ssDNA secondary structu...
The recombination activating gene (RAG) is a lymphoid-specific endonuclease involved in the V(D)J re...
Piwi-interacting piRNAs are a major and essential class of small RNAs in the animal germ cells with ...
Abstract: The MobM relaxase (494 amino acids) encoded by the promiscuous streptococcal plasmid pMV15...
High mobility group box (HMGB) proteins are non-histone architectural proteins that bind to and bend...
Eukaryotes regulate gene expression and other nuclear processes through the posttransla-tional modif...
Repair of DNA breaks by single-strand annealing (SSA) is a major mechanism for the main-tenance of g...
D ow nloaded from 2 Active equi-paritioning of the F plasmid is achieved by its sopABC gene. SopA bi...