The ability of soluble factors to modulate the growth of a virulent strain of Mycobacterium avium in murine peritoneal macrophages was studied. The virulent strain, TMC 702, grew progressively in the organs of susceptible BALB/C mice. In addition, this strain of M. avium grew progressively in untreated peritoneal macrophages. Treatment of macro-phage monolayers with interferon-gamma (IFN--y) did not change significantly the in-tracellular growth of M. avium. Addition of indomethacin to IFN--y-treated macrophage monolayers rendered them significantly more bacteriostatic than macrophages treated with interferon alone, suggesting a role for prostaglandins in inducing unresponsive-ness to IFN--y in infected cells. Additionally, treatment with t...
IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-...
Natural killer (NK) cells from spleens of normal and Mycobacterium avium complex (MAC)-infected C57 ...
Opportunistic infections with non-tuberculous mycobacteria such as Mycobacterium avium are receiving...
Inbred strains of mice, notably the susceptible C57BL/6 and the resistant NJ strains of mice, were i...
The most important immunopathological consequence of experimental mycobacterial infection is the sup...
The most important immunopathological consequence of experimental mycobacterial infection is the sup...
Antigen A60 from Mycobacterium bovis bacillus Calmette Guérin was shown to trigger both humoral and ...
International audienceThe mechanisms through which immune and inflammatory responses stimulate the e...
We have previously demonstrated that granuloma macrophages from the foot pads of Mycobacterium Iepra...
To investigate whether infection with Mycobacterium avium modifies the cytokine response of human ma...
Our group has previously described that murine peritoneal macrophages treated in vitro for 7 days wi...
An effective intracellular concentration of an antimicrobial agent is essential for therapy of infec...
Our group has previously described that murine peritoneal macrophages treated in vitro for 7 days wi...
IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-...
The bactericidal function of macrophages was investigated in congenic mice expressing the phenotype ...
IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-...
Natural killer (NK) cells from spleens of normal and Mycobacterium avium complex (MAC)-infected C57 ...
Opportunistic infections with non-tuberculous mycobacteria such as Mycobacterium avium are receiving...
Inbred strains of mice, notably the susceptible C57BL/6 and the resistant NJ strains of mice, were i...
The most important immunopathological consequence of experimental mycobacterial infection is the sup...
The most important immunopathological consequence of experimental mycobacterial infection is the sup...
Antigen A60 from Mycobacterium bovis bacillus Calmette Guérin was shown to trigger both humoral and ...
International audienceThe mechanisms through which immune and inflammatory responses stimulate the e...
We have previously demonstrated that granuloma macrophages from the foot pads of Mycobacterium Iepra...
To investigate whether infection with Mycobacterium avium modifies the cytokine response of human ma...
Our group has previously described that murine peritoneal macrophages treated in vitro for 7 days wi...
An effective intracellular concentration of an antimicrobial agent is essential for therapy of infec...
Our group has previously described that murine peritoneal macrophages treated in vitro for 7 days wi...
IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-...
The bactericidal function of macrophages was investigated in congenic mice expressing the phenotype ...
IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-...
Natural killer (NK) cells from spleens of normal and Mycobacterium avium complex (MAC)-infected C57 ...
Opportunistic infections with non-tuberculous mycobacteria such as Mycobacterium avium are receiving...