Radioprotective Role of Gymnemic Acid on Mice: Study on Hepatic Biochemical Alterations

Abstract: The aim of the present study was to evaluate the radioprotective effect of Gymnemic acid (GA) on Swiss albino mice against radiation induced hepatic biochemical alterations. Swiss albino mice (6–8 weeks) were divided into three groups. Group I (Normal) was without any treatment. Group II (Control) was only irradiated group (8Gy). Group III (GA+Irradiated) Mice in this group received GA orally (350 mg / Kg.b.wt / day) one hour before radiation (8 Gy) exposure. Mice were sacrificed on days 1, 3 and 7, post-irradiation. Radiation induced deficit in hepatic GSH and protein levels was significantly increased, whereas radiation induced elevation of lipid peroxidation level was markedly averted in GA pre-treated animals than those of irradiated group. It showed that GA provides protection against radiation-induced biochemical alterations in liver of Swiss albino mice