Mohammad-Mehdi Sagheb MD*, Ghanbar-Ali Rais-Jalali MD*,

Background: Pancreas transplantation is the treatment of choice for selected patients with type 1 diabetes mellitus. We reviewed our first 40 patients who underwent pancreas transplantation in Shiraz Organ Transplant Center. Methods: Between April 2006 and April 2008, we performed pancreas transplantation on 40 recipients. The operation included portal venous drainage and exocrine enteric drainage. Immunosuppressive therapy included prednisolone, tacrolimus, and mycophenolate mofetil. Ganciclovir was administered as prophylaxis for cytomegalovirus. Peri-operative and regular follow up data on survival and complication were gathered and analyzed. Results: The mean follow-up was 10.1±6.5 months (range: 1 – 24 months). Mean age of donors and recipients was 23.6±8.2 and 32.30±8.9 years, respectively. The mean pretransplant insulin consumption was 43.75±17.4 IU. Fasting blood glucose before transplantation was 275.5±72.3 mg/dL that decreased to 95.6±7.01 at six months follow-up (P<0.001). Complications were as follows: re-exploration (n=9), gastrointestinal complications (n=10), acute rejection episodes (n=12), and chronic rejection (n=4). We lost one patient due to diffuse cytomegalovirus and aspergillus infection three months after the operation with a functioning graft. Overall graft survival was 84.9 % and patient survival 97.5%. Conclusion: Good patient and graft survival in these series encouraged us to continue the program with all its difficulties