Add to ORKGuracil (5-FU) administered by pro-tracted intravenous infusion have suggested an improved response rate and decreased toxicity profile when compared with 5-FU given by bolus in-jection in patients with metastatic colorectal cancer. Additional studies have suggested further enhancement of infusion 5-FU activity when it is com-bined with low-dose weekly cisplatin administration. Purpose: This phase III study in adults with metastatic colorec-tal cancer was planned as a compari-son of objective response rates, toxicity, and survival in patients receiving bolu
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fl...
Background: Hydroxyurea (HU), an inhibitor of ribonucleotide reductase, may potentiate the activity ...
Continuous-infusion (c.i.) 5-fluorouracil (5-FU) can overcome resistance to bolus 5-FU, and leucovor...
Background: Phase II studies of fluorouracil (5-FU) administered by protracted intravenous infusion ...
of bolus fluorouracil (5-FU) by addi-tion of leucovorin to the treatment regimen has increased respo...
Background: A phase III study was started to compare oxaliplatin/5FU/LV in the first-line with bolus...
Sunmary Bolus infusional 5-fluorouracil (5-FU) and folinic acid (FA) is reported to be highly active...
Purpose: This trial was conducted to determine whether high-dose fluorouracil (FU) given as a weekly...
The primary objective of this trial was to determine the objective response of two regimens with CDD...
PURPOSE: We performed a phase I study of 5-fluorouracil (5-FU), cisplatin and irinotecan. METHODS: T...
Purpose: To investigate if double modulation of fluo-rouracil 5-FU) with leucovorin (folinic acid [F...
To demonstrate that adding irinotecan to a standard weekly schedule of high-dose, infusional fluorou...
OBJECTIVE: The primary objective of this trial was to determine the objective response of two regime...
A consecutive phase I and phase II study of a 14-days continuous infusion schedule of 5-fluorouracil...
Snuunary We have conducted a retrospective study of high-dose folimc acid and 5-fluorouracil in % pa...
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fl...
Background: Hydroxyurea (HU), an inhibitor of ribonucleotide reductase, may potentiate the activity ...
Continuous-infusion (c.i.) 5-fluorouracil (5-FU) can overcome resistance to bolus 5-FU, and leucovor...
Background: Phase II studies of fluorouracil (5-FU) administered by protracted intravenous infusion ...
of bolus fluorouracil (5-FU) by addi-tion of leucovorin to the treatment regimen has increased respo...
Background: A phase III study was started to compare oxaliplatin/5FU/LV in the first-line with bolus...
Sunmary Bolus infusional 5-fluorouracil (5-FU) and folinic acid (FA) is reported to be highly active...
Purpose: This trial was conducted to determine whether high-dose fluorouracil (FU) given as a weekly...
The primary objective of this trial was to determine the objective response of two regimens with CDD...
PURPOSE: We performed a phase I study of 5-fluorouracil (5-FU), cisplatin and irinotecan. METHODS: T...
Purpose: To investigate if double modulation of fluo-rouracil 5-FU) with leucovorin (folinic acid [F...
To demonstrate that adding irinotecan to a standard weekly schedule of high-dose, infusional fluorou...
OBJECTIVE: The primary objective of this trial was to determine the objective response of two regime...
A consecutive phase I and phase II study of a 14-days continuous infusion schedule of 5-fluorouracil...
Snuunary We have conducted a retrospective study of high-dose folimc acid and 5-fluorouracil in % pa...
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fl...
Background: Hydroxyurea (HU), an inhibitor of ribonucleotide reductase, may potentiate the activity ...
Continuous-infusion (c.i.) 5-fluorouracil (5-FU) can overcome resistance to bolus 5-FU, and leucovor...