Contribution Chemistry of Trifluoroacetimidoyl Halides as Versatile Fluorine-containing Building Blocks

The trifluoromethyl group involved in organic compounds plays important roles as a key functional group in medicine, agricultural chemicals and electronic materials like liquid crystals. Common methods for introducing the trifluoromethyl group (CF3 group) into organic compounds are categorized into three; 1) the use of building blocks containing CF3 group, 2) trifluoromethylation by the use of trifluoromethylating agents such as CF3-TMS, FSO2CO2Me, CF3I, etc., and 3) the transformation of a functional group such as CCl3 and CO2H groups to CF3 group by the use of fluorinating agents such as F2 and HF. The method 3 is conventionally used for the industrial mass production of CF3-containing molecules, which are mostly structurally simple and stable molecules. On the other hand, methods 1 and 2 have been used for the structurally complex an