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Multiple sclerosis and sweating 2 This investigation tested the hypothesis that cholinergic sweat function of individuals with multiple sclerosis (MS; n=10) is diminished relative to matched healthy control subjects (CON, n=10). In addition, cholinergic sweat function was determined prior to and following 15 weeks of aerobic training in a subgroup of individuals with MS (MS-EX, n=7). Cholinergic sweating responses were assessed via pilocarpine iontophoresis on ventral forearm skin. A collection disc placed over the stimulated area collected sweat for 15 minutes. Sweat rate (SR) was calculated by dividing sweat collector volume by collection area and time. Iodine-treated paper was applied to the stimulated area to measure number of activated sweat glands (ASG). Sweat gland output (SGO) was calculated by dividing SR by density of glands under the collector. Sweat gland function was determined in MS-EX to test the hypothesis that exercise training would increase sweating responses. No differences in ASG were observed between MS and CON. SR and SGO in MS (0.18 ± 0.08 mg•cm-2•min-1; 1.74 ± 0.79 µg•gld-1•min-1) were significantly lower (P 0.05) than CON (0.27 ± 0.10 mg•cm-2•min-1; 2.43 ± 0.69 µg•gld-1•min-1) respectively. Aerobic exercis