Second Primary Cancer after Treatment for Cervical Cancer An International Cancer Registries Study

Background. The pattern of second cancers after treatment for cervical cancer provides important infor-mation on the risk of radiation-induced malignancies. Large numbers of women survive many years and can be studied for late effects. Methods. Incident second cancers in 86,193 patients with cervical cancer reported to 13 population-baaed can-cer registries in 5 countries were evaluated to estimate the risk of second cancer among very long term survi-vors. Results. Overall, 7543 second cancers were observed versus 6015 cancers expected based on population rates (observed/expected = 1.2). Lung cancer accounted for nearly half of the excess cancers. Among the 49,82