Drug Resistance and/or Drug Tolerance of Malignant Tertian Malaria Cases to Chloroquine in the Armed Forces of the Philippines (January 1975-June 1979)*

A total of 4,630 Malaria cases were admitted and treated at the Army General Hospital for a period from January 1975 to June 1979 broken down into Plasmodium falciparum malaria 3,061; Plasmodium vivax malaria 1,145; Plasmodium malariae malaria 273; mixed infection 105; and 56 resistant cases. Although in vitro and in vivo susceptibility test showed R1 resistance, repeated treatment with the same or higher dose of chloroquine led to the of parasitemia and disappearance of the clinical manifestations. Besides the percentage of the level of significance of true resistance in these studies were not attained (0.012%). However, we should be aware and cognizant of significant value to warrant true resistance to chloroquine of the malaria parasites and or individual drug tolerance. [Phil J Microbio