1. STUDY TITLE: An examination of the association between fatigue, vitality and sleep disturbance, and neurocognitive functioning in adult survivors of childhood cancer. 2. WORKING GROUP AND INVESTIGATORS:

As enhanced medical treatments have contributed to an increase in the number of adult survivors of childhood cancer, a good deal of research has been devoted to medical and psychosocial late effects.1-4 Two of the common quality of life late effects include neurocognitive impairment and cancer-related fatigue. This study aims to examine the association between these two outcomes by examining the impact of fatigue and vitality, as well as sleep quality, on neurocognitive functioning; an area that has yet to receive much attention in adult survivors of childhood cancer. Among the neurocognitive effects associated with childhood cancer, research has shown common impairment in specific domains including, but not limited to, processing speed, attention, and memory.1-3 However, reduced sleep quality and fatigue alone are also thought to impact some of the same aforementioned neurocognitive skills. For example, among adults who were diagnosed with chronic fatigue syndrome, specific neurocognitive deficits such as slow processing speed, impaired working memory, and poor memory and learning of new information has been reported.5,6 Moreover, the presence of significant fatigue has been associated with poor neuropsychological functioning in adults following acute medica