Studies to Evaluate Novel Neuroprotectants in a Rat Model of Soman Exposure Reveal Episodes of Status Epilepticus and Spontaneous Recurrent Seizures Even with Initial

Introduction: The threat of exposure to organophosphorus (OP) nerve agents exists on the battlefield, as a result of terrorism, and as part of current demilitarization efforts. Control of seizures resulting from OP exposure and means to mitigate central nervous system damage continue to be a major military and civilian research goal. Status epilepticus (SE), a primary outcome of exposure to OP nerve agents, triggers a pathophysiological cascade of central nervous system molecular events beginning with elevate