Human Reproduction vol.14 no.4 pp.1137–1139, 1999 Letters to the Editor

A 47,XXY fetus resulting from ICSI in a man with an elevated frequency of 24,XY spermatozoa Dear Sir, There has been considerable debate and controversy about gen-etic risks associated with intracytoplasmic sperm injection (ICSI) (Martin, 1996; Persson et al., 1996). As well as concerns about the increased frequency of the cystic fibrosis transmem-brane regulator mutations and Y chromosome deletions in infer-tile males, there is also mounting evidence of increased risks for chromosomal abnormalities following ICSI. Studies of infertile men have repeatedly demonstrated an increased frequency of constitutional chromosomal abnormalities which are mainly sex chromosomal abnormalities and translocations (Montag et al., 1997; Pauer et al., 1997). Reports based on prenatal diagnosis in ICSI pregnancies have indicated an increased risk of se