CHING-LIANG HO

Bone marrow angiogenesis and its clinical correlates in myelofibrosis with myeloid metaplasia The term myelofibrosis with myeloidmetaplasia (MMM) describes a clonalstem cell disorder that is characterized by bone marrow myeloproliferation associ-ated with a polymorphic stromal reaction including myelofibrosis, osteosclerosis, and angiogenesis.1 The median survival ranges from 2 to more than 15 years depending on the presence or absence of well-defined prognostic factors including age, hemoglobin level, leukocyte count, hypercatabolic symp-toms, and circulating myeloblast percent-age.2,3 Interestingly, neither the degree of bone marrow fibrosis nor spleen size ha