Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease: an overview

Subject headings Helicobacter pylori; Helicobacter infection; gastric acid; gastric mucosa; duodenal ulcer; bicarbonates; gastric metaplasia Olbe L, F ndriks L, Hamlet A, Svennerholm AM, Thoreson AC. Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease: an overview. World J Gastroentero, 2000;6(5):619-623 Duodenal ulcer (DU) can be developed via several different mechanisms. Hypersecretion of gastric acid is, however, a common denominator. A massive hypersec retion of acid can by itself evoke a DU, e.g. in the Zollinger-Ellison syndrome. Irrespective of the mechanism behind the development of a DU, powerful antisecretory treatment will heal the ulcer and prevent recurrence