Cytokine gene polymorphisms in acute pancreatitis

Context Pro-inflammatory and regulatory cytokines play a key role in the pathogenesis of acute pancreatitis. Genetic loci encoding cytokines have been shown to be polymorphic, in some cases influencing protein expression. Objective To investigate if TNF and IL-10 gene loci are associated with the occurrence or severity of acute pancreatitis. Setting Acute surgical unit within large district hospital serving a population o