In diseases caused by a deleterious gene mutation, knowledge of age-specific cumulative risks is necessary for medical management of mutation carriers. When pedigrees are ascertained through at least one affected individual, ascertainment bias can be corrected by using a parametric method: the Proband’s phenotype Exclusion Likelihood or PEL. This method, using a survival analysis approach based on the Weibull model, has been shown to be unbiased when family samples are simulated from aWeibull distribution. This paper proposes a nonparametric method for penetrance function estimation that corrects for ascertainment on at least one affected: the Index Discarding EuclideAn Likelihood or IDEAL. IDEAL is compared with PEL, using family samples s...