BRIEF COMMUNICATION Dose-Dependent Effects of Dietary - and -Tocopherols on Genetic Instability in Mouse Mutatect Tumors

Vitamin E in foodstuffs is a mixture of tocopherols. In mouse Mutatect tu-mors, a model designed to detect DNA mutations, the hypoxanthine phos-phoribosyltransferase (Hprt) gene mutation frequency is associated with the number of tumor-infiltrating neu-trophils and both are markedly de-creased in mice fed high levels of -tocopherol. Dietary -tocopherol is also associated with a decrease in neutrophil-associated loss of an inter-leukin 8 (IL-8)-expressing transgene in this tumor model. We examined Hprt gene mutation frequency (ex