Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects

We investigated association between polymorphisms in DNA repair genes and the capacity to repair DNA damage induced by g-irradiation and by base oxidation in a healthy population. Irradiation-specific DNA repair rates were significantly decreased in individuals with XRCC1 Arg399Gln homozygous variant genotype (0.45 ± 0.47 SSB/ 109 Da) than in those with wild-type genotype (1.10 ± 0.70 SSB/109 Da, P 0.0006, Mann–Witney U-test). The capacity to repair oxidative DNA damage was significantly decreased among individuals with hOGG1 Ser326Cys homozygous variant genotype (0.37 ± 0.28 SSB/109 Da) compared to those with wild-type genotype (0.83 ± 0.79 SSB/109 Da, P 0.008, Mann–Witney U-test). Investiga-tion of genotype combinations showed that the increasing number of variant alleles for both XRCC1 Arg399Gln an