Pages 273–286 Immunotherapy of multiple sclerosis—Current practice and future directions

Abstract—Over the past decade, multiple sclerosis (MS) has become a treatable neurological disease. This paper reviews the therapies that have been studied to treat MS and discusses various treatment approaches on the horizon. Immunosuppres-sive and immunomodulatory therapies have been shown to alter the long-term course of MS. Therapies are currently avail-able for relapsing-remitting, secondary progressive, and pro-gressive relapsing disease. Although effective, these therapies have a modest impact on reduction in relapse rate and slowing of disease progression. Much work is needed to improve upon this modest effect and hopefully obtain a cure. Key words: disease-modifying agents, immunomodulatory, immunosuppressive, immunotherapy, multiple sclerosis, treatment