Growth Hormone Stimulation Tests in the Differential Diagnosis of Parkinson’s Disease

Idiopathic Parkinson’s disease (IPD) is a common neurodegenerative disorder whose differential diagnosis from other forms of atypical parkinsonism, for instance multiple system atrophy (MSA) or progressive supranuclear palsy, may be difficult, especially in the early stages. Growth hormone stimulation tests have been recently reported to be useful in the differential diagnosis between IPD and MSA. Both clonidine, an α2-adrenoceptor agonist, and arginine, an amino acid activating the cholinergic system, have been used to assess growth hormone response in patients with IPD and MSA.This review summarizes the results of several studies and discusses the validity of these tests in the differential diagnosis of parkinsonisms