Chitosan Beads as a New Gastroretentive System of Verapamil

The main objective of this project is to design a new extended release gastroretentive mutiparticulate delivery system for verapamil (VP) by incorporation into hydrogel beads made of chitosan. The beads were formed by dropping solutions of VP and chitosan in a solution of tripolyphosphate using a syringe pump with adjustable constant rate. The formed beads were then further crosslinked using glutraldehyde and the excess glutraldehyde were then washed. The physical properties of the prepared beads such as beads sizes, shapes, friabilities and loading efficiencies were determined. The floating characteristics and the release profiles were also studied. The produced beads from all batches showed a very good spherical geometry with mean diameter in the range of 1.3 – 2.0 mm. The drug loading efficiency was around 42 % for all batches. The % friabilities were less than 1 % indicating that the beads surfaces are highly resistant to attrition. Batche