589Pseudallescheria boydii Infection o Pathologic Confirmation

disseminated disease (3).cerebrospinal fluid was nonreactive to the VDRL, and the results of tests for cryptococcal antigen were negative. Contrast-enhanced computed tomography (CT) showed ependymal enhancement in the frontal horn of the right lateral ventricle (Fig 1A). Magnetic resonance (MR) imaging of the brain showed focal punctate enhancement The frequency of CNS infection with P boydii has increased in the last two decades because of the increasing numbers of immunocompro-mised patients (3). Of 25 reported cases of CNS infection, 10 patients were immunocompro