Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of folate receptor (FR)– positive malignant tissue (e.g., ovarian carcinomas). However, substantial FR expression in the kidneys results in undesired re-nal retention of radioactivity. Recently, we found that the prein-jection of an antifolate significantly improved tumor selectivity of organometallic 99mTc-radiofolates in mice. The aim of this study was to corroborate the effect of pemetrexed with the clin-ically tested 111In-DTPA-folate (DTPA is diethylenetriaminepen-taacetic acid) in a human ovarian cancer xenografted mouse model. Methods: In vivo studies were performed in female athymic nude mice bearing subcutaneous FR-positive ovarian tumors...
A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, m...
Targeted radionuclide therapy is based on systemic application of particle-emitting radiopharmaceuti...
Purpose: For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma ...
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of fo...
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of fo...
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of fo...
Folic-acid-based radioconjugates have been developed for nuclear imaging of folate receptor (FR)-pos...
Folate-based radiopharmaceuticals have the potential to be used for imaging and therapy of tumours p...
Targeting the folate receptor (a-FR) with radiolabeled folates for the noninvasive diagnosis and the...
Folate receptor (FR) targeting is an attractive strategy for nuclear imaging of cancer and activated...
The development of radiolabeled folate-chelate conjugates could result in clinically useful diagnost...
A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, m...
The cell-membrane folic acid (FA) receptors are known to be responsible for cellular accumulation of...
Purpose: The folate receptor (FR) is a valuable tumour marker, since it is frequently overexpressed ...
INTRODUCTION Application of therapeutic folate radioconjugates is a promising option for the treatm...
A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, m...
Targeted radionuclide therapy is based on systemic application of particle-emitting radiopharmaceuti...
Purpose: For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma ...
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of fo...
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of fo...
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of fo...
Folic-acid-based radioconjugates have been developed for nuclear imaging of folate receptor (FR)-pos...
Folate-based radiopharmaceuticals have the potential to be used for imaging and therapy of tumours p...
Targeting the folate receptor (a-FR) with radiolabeled folates for the noninvasive diagnosis and the...
Folate receptor (FR) targeting is an attractive strategy for nuclear imaging of cancer and activated...
The development of radiolabeled folate-chelate conjugates could result in clinically useful diagnost...
A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, m...
The cell-membrane folic acid (FA) receptors are known to be responsible for cellular accumulation of...
Purpose: The folate receptor (FR) is a valuable tumour marker, since it is frequently overexpressed ...
INTRODUCTION Application of therapeutic folate radioconjugates is a promising option for the treatm...
A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, m...
Targeted radionuclide therapy is based on systemic application of particle-emitting radiopharmaceuti...
Purpose: For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma ...