THE CLESH DOMAIN OF HISTIDINE-RICH GLYCOPROTEIN IS IMPORTANT FOR MODULATION OF THE TSP-1-CD36 ANTI-ANGIOGENIC PATHWAY

INTRODUCTION: Normal tissue homeostasis requires a precise maintenance of balance between angiogenic inducers and inhibitors. Thrombospondins-1 and-2 are highly regulated matricellular proteins that have been shown to function in vivo to inhibit angiogenesis in multiple conditions, including the cutaneous wound healing response and in some tumor beds. Our lab, in collaboration with Bouck and colleagues1,2, identifie