Association of Interleukin-10 Promoter Single Nucleotide Polymorphisms 819 T/C and 592 A/C With Aging

Increased inflammatory activity is known to accompany aging. Single nucleotide polymorphisms of inflammatory mediator genes might therefore affect the aging process. Relation of eight SNPs (tumor necrosis factor-a [TNF-a]1031 T/C, interleukin-10 [IL-10]819 T/C, IL-1b511 C/T, IL-6 634 C/G, IL-18 607 A/C, transforming growth factor-b [TGF-b] þ869 C/T, matrix metalloproteinase-1 [MMP-1]1607 1G/2G, and MMP-31171 5A/6A) with age or gender was evaluated in 500 Japanese persons (mean age: 56.7 years old, range: 19–100) by the chi-square test. There was a significant association of IL-10819 T/C with age ( p .0026). The association remained significant after multivariate logistic regression analysis (odds ratio for an age interval for 1 year, 1.009; 95 % CI, 1.002–1.016). Furthermore, the genotype distribution of IL-10819 T/C was completely consistent with that of592 A/C. These data suggest that IL-10819 T/C and592 A/C may be a promising candidate for an aging-related gene in a Japanese population. NOWADAYS, a gene–longevity association study ofunrelated individuals is one of the most popular study designs used to clarify the molecular basis of inherited components in human longevity (1). A variety of genes involved in DNA repair, drug or lipid metabolism, immun