Toxicity Study of Pueraria mirifica Airy shaw et Suvatabandhu

of which the ovaries are cut out, we found that the weight and fluid levels in the womb increased in the same manner as was found in mice receiving ethinyl-estradiol. In addition, there is a report that pueraria mirifica worked well in female mice, as a contraceptive at the dosage of 1 gram per week. As for the male mice, pueraria mirifica reduced the sexual iactivity of mice, by reducing testicular weight, epididymis, adrenal glands, seminal vesicles, sperm counts and the percentage of sperm motility. In a toxicity study, it was shown that a water extract of pueraria mirifica killed mice with surgically removed ovaries, within 2-3 minutes, but produced estrogenic effects by increasing womb weights, when the dosage was lowered. The study showed that when mice were fed 100 mg per kilogram of body weight, appetites decreased, liver cells became infected. and bled, sperm counts lowered and Leydig cells were destroyed. In a study of Japanese partridges, it was found that pueraria mirific