The Challenge of Achieving National Cholesterol Goals in Patients With Diabetes

OBJECTIVE — This study analyzed lipid results from a large community-based population of patients with diabetes to assess the feasibility of attaining the standard and new optional LDL-based lipid goals using currently available lipid-lowering medications. RESEARCHDESIGNANDMETHODS — Ambulatory patients with diabetes who were interviewed as part of the Vermont Diabetes Information System trial with a reported LDL were analyzed. Patients were categorized into high-risk and very-high-risk cardiovascular status. For patients not at the LDL goal, the required changes in therapy to achieve the goal were assessed. RESULTS — Of the entire cohort, 49.4 % (321 of 650) had LDL100 mg/dl. According to the National Cholesterol Education Program, 29.4 % (191 of 650) of patients were very high risk and have an optional LDL goal of70 mg/dl. Only 15.7 % (30 of 191) of very-high-risk patients had an LDL70 mg/dl. Based on our analysis of high-risk patients, 17 of 459 (3.7%) would require more than two lipid-lowering drugs to achieve an LDL100 mg/dl. In the very-high-risk group, we estimate that 26.2 % (50 of 191) of patients will not reach LDL 70 mg/dl with two lipid-lowering medications. CONCLUSIONS — In many patients with diabetes and cardiovascular disease, it will be difficult to attain an LDL goal of 70 mg/dl. Approximately 25 % of patients will require more than two lipid-lowering drugs at maximal doses to attain this goal, assuming 100 % tolerance of lipid-lowering medications