Abstract. Tracking of a reference signal (assumed bounded with essentially bounded deriva-tive) is considered in the context of a class Σρ of multi-input, multi-output dynamical systems, modelled by functional differential equations, affine in the control and satisfying the following struc-tural assumptions: (i) arbitrary—but known—relative degree ρ ≥ 1; (ii) the “high-frequency gain” is sign definite—but possibly of unknown sign. The class encompasses a wide variety of nonlinear and infinite-dimensional systems and contains (as a prototype subclass) all finite-dimensional, linear, m-input, m-output, minimum-phase systems of known strict relative degree. The first control objec-tive is tracking, by the output y, with prescribed accuracy: gi...