in Patients with Coronary Artery Disease

We have recently demonstrated the potential of 18F-FDG as an imagingmarker ofmyocardial ischemia if injectedat peakexercise. However, how long increased 18F-FDG uptake can be observed after an episode of exercise-induced myocardial ischemia is not known. We performed the current study to determine whether in-creased regionalmyocardial 18F-FDGuptakeatexercise inpatients with coronary artery disease (CAD) persists on rest imaging (24 h later), after an episode of exercise-induced myocardial ischemia. Methods: Twenty-four patients with suspected CAD underwent exercise 99mTc-sestamibi and 18F-FDG imaging. Repeated 18F-FDG imaging was performed 24 h after exercise imaging, after an injection of a seconddose of 18F-FDGat rest in 20 patients. Per-fusion imaging with 99mTc-sestamibi was simultaneously per-formed with 18F-FDG imaging. All patients underwent coronary angiography.Results: Eighteen patients had greater than or equa