The levels of C-reactive protein in women treated by IVF

BACKGROUND: The complex regulation of endometrial receptivity and embryo implantation involves cytokines, several of which are stimulators of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the concentrations of serum CRP in women treated by IVF. METHODS: Seventy-two women who underwent IVF treatment were prospectively studied. The levels of serum CRP were evaluated on the following days: oocyte retrieval, embryo transfer, 5, 6 or 7 days afterwards and 12 days after embryo transfer. RESULTS: CRP levels increased from 6.8 6 9.5 mg/l on oocyte retrieval day to 14.6 6 12.5 mg/l on days 5±7 post-transfer (P < 0.0001). The ratios of CRP levels for transfer day/pick-up day were 1.2 in women who conceived versus 2.5 in the non-pregnant group (P = 0.01). CONCLUSION: In women treated by IVF the concentrations of CRP in blood increase signi®cantly during the ®rst week following oocyte retrieval. Successful outcome is associated with a relative small increment in CRP on the day of embryo transfer. Key words: C-reactive protein/cytokine/IVF/uterine receptivit