With the start of Run II at the Fermilab Tevatron a host of new physics opportunities are opened. In this paper we will review the prospects for physics at the CDF and DØ experiments. Topics ranging from QCD, to electro-weak precision measurements, to top-quark physics, to searches for the Higgs boson and signals of physics beyond the Standard Model will be discussed. B-Physics at the Tevatron is covered in a separate contribution to these proceedings. We will outline how upgrades to the accelerator and the detectors make these studies possible with precisions higher than ever achieved previously and will show results from the first data collected in Run II. These results give us confidence in our ability to achieve ambitious physics goals,...