Add to ORKGRecently, the somatostatin receptor subtype 2 (SSTR2) selective antagonist sst2-ANT was determined to have a high affinity for SSTR2. Additionally, 111In-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-sst2-ANT showed high uptake in an SSTR2-transfected, tumor-bearingmousemodel and suggested that radiolabeled SSTR2 antagonistsmay be superior to agonists for imaging SSTR2-positive tumors. This report describes the synthesis and evaluation of 64Cu-CB-4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane-sst2-ANT (64Cu-CB-TE2A-sst2-ANT) as a PET radiopharmaceutical for the in vivo imaging of SSTR2-positive tumors.Methods: Receptor-binding studies were performed to determine the dissociation con-stant of the radiopharmaceut...
Somatostatin receptors (sstrs) are G-protein coupled receptors that modulate hormone secretions. The...
Abstract Background The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of lumina...
PURPOSE: Somatostatin receptor (sst) targeting is an established method to image and treat sst-posit...
Recently, the somatostatin receptor subtype 2 (SSTR2) selective antagonist sst2-ANT was determined t...
Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical applicati...
Somatostatin receptor targeting of neuroendocrine tumors using radiolabeled somatostatin agonists is...
International audienceIdentified in 1973, somatostatin (SST) is a cyclic hormone peptide with a shor...
The goal of this research is to develop 64Cu radiolabeled somatostatin-receptor ligands for position...
Purpose: Targeting of tumours positive for somatostatin receptors (sst) with radiolabelled peptides ...
Although radiolabeled somatostatin analogs have become highly prevalent in the diagnosis and treatme...
Radiolabeled somatostatin analogs have become powerful tools in the diagnosis and staging of neuroen...
Abstract Background Somatostatin receptor targeting radiopeptides are successfully being used to ima...
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin rec...
Somatostatin-based radioligands have been shown to have sensitive imaging properties for neuroendocr...
Targeting neuroendocrine tumors expressing somatostatin receptor subtypes (sst) with radiolabeled so...
Somatostatin receptors (sstrs) are G-protein coupled receptors that modulate hormone secretions. The...
Abstract Background The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of lumina...
PURPOSE: Somatostatin receptor (sst) targeting is an established method to image and treat sst-posit...
Recently, the somatostatin receptor subtype 2 (SSTR2) selective antagonist sst2-ANT was determined t...
Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical applicati...
Somatostatin receptor targeting of neuroendocrine tumors using radiolabeled somatostatin agonists is...
International audienceIdentified in 1973, somatostatin (SST) is a cyclic hormone peptide with a shor...
The goal of this research is to develop 64Cu radiolabeled somatostatin-receptor ligands for position...
Purpose: Targeting of tumours positive for somatostatin receptors (sst) with radiolabelled peptides ...
Although radiolabeled somatostatin analogs have become highly prevalent in the diagnosis and treatme...
Radiolabeled somatostatin analogs have become powerful tools in the diagnosis and staging of neuroen...
Abstract Background Somatostatin receptor targeting radiopeptides are successfully being used to ima...
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin rec...
Somatostatin-based radioligands have been shown to have sensitive imaging properties for neuroendocr...
Targeting neuroendocrine tumors expressing somatostatin receptor subtypes (sst) with radiolabeled so...
Somatostatin receptors (sstrs) are G-protein coupled receptors that modulate hormone secretions. The...
Abstract Background The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of lumina...
PURPOSE: Somatostatin receptor (sst) targeting is an established method to image and treat sst-posit...