1Department of Synthetic Chemistry and Biological

The volume of sequence information from the human genome project demands the development of a tool to rapidly scan DNA for mutations. Such a technology would also be valuable in cancer research as a tool to detect early mutation events. Today, single nucleotide polymorphisms (SNPs), are routinely detected using methods that rely largely on the separation of DNA fragments by gel electrophoresis or HPLC, neither of which are readily suited to high throughput analysis. This review discusses how Biacore’s SPR technology may come to fill this role