Assessment of plasma brain natriuretic peptide concentration in Boxers with arrhythmogenic right ventricular

www.vetdiag.com Natriuretic peptides have been shown to be useful diagnostic aids in the management of canine heart disease and heart failure. NT-proBNP and BNP are released in a 1:1 fashion. However, BNP has a short plasma half life of approximately 90 seconds in dogs resulting in lower concentrations relative to NT-proBNP. For this reason VDxI offers a canine-specific assay to detect NT-proBNP that exploits its expanded half-life and higher concentrations. Human and canine proBNP are less homologous than human and canine proANP. Canine proBNP and human proBNP are only 46 % homologous compared to 87 % homology for canine and human proANP. This makes it necessary to use assays that are canine specific when evaluating proBNP levels. Alves de Souza RC, Camacho AA. Neurohormonal, hemodynamic, and electrocardiographic evaluations of healthy dogs receiving long-term administration o